Fig. 7 | Scientific Reports

Fig. 7

From: Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling

Fig. 7

Double variable flow cytometry dot plots for (A) BT-474 and (B) SKBR3 cells analyzing pro-apoptotic effects of control (left panel) and liquiritin-treated cells (right panel) using Annexin V-FITC and propidium iodide (PI) dual staining. LL quadrant (FITC−/PI−) represents living cells; LR quadrant (FITC+/PI−) shows early apoptotic cells; UL quadrant (FITC−/PI+) depicts necrotic cells; and UR quadrant (FITC+/PI+) denotes late apoptotic cells. (C) Effect of liquiritin on the expression of caspases 3, 8, and 9 in BT-474 cells. Vertical bars represent fold change of expression ± SD as compared with untreated cells.

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