Table 1 Enriched genes in two groups of autophagy-related pathways.
ID | PATHWAY | gene_UP_list MMvsMN | gene_DOWN_list MPvsMM |
|---|---|---|---|
mmu04068 | FOXO signaling pathway | Gabarap,Fbxo32,Igf1r,Pik3r1,Foxo1,Rbl2, Pik3ca,Gadd45b,Irs2,Prkag2,Plk3,Egfr, Bcl2l11,Insr,Foxo3,Bnip3,Gabarapl1, Gadd45g,Akt1,Cdkn1a | Igf1r,Gadd45b,Prkag2, Gabarapl1 |
mmu04115 | p53 signaling pathway | Igfbp3,Gadd45b,Bcl2l1,Thbs1,Siah1a,Sesn2, Sesn1,Cd82,Gadd45g,Fas,Cdkn1a | Gadd45b,Cd82 |
mmu04137 | Mitophagy—animal | Gabarap,Ulk1,Atf4,Map1lc3b,Optn,Bcl2l1, Ubc,Nbr1,Tax1bp1,Bnip3l,Sqstm1,Ubb, Tbc1d15,Foxo3,Bnip3,Gabarapl1 | Ubc,Gabarapl1 |
mmu04140 | Autophagy—animal | Gabarap,Ulk1,Igf1r,Pik3r1,Nrbf2,Map1lc3b, Ddit4,Pik3ca,Zfyve1,Bcl2l1,Ern1,Irs2, Mtmr14,Smcr8,Uvrag,Rb1cc1,Dapk1, Sqstm1,Bnip3,Atg13,Gabarapl1,Ctsl,Akt1 | Igf1r,Smcr8,Gabarapl1 |
mmu04150 | mTOR signaling pathway | Ulk1,Lpin1,Cab39,Eif4ebp1,Igf1r,Pik3r1, Atp6v1b2,Atp6v1h,Slc7a5,Ddit4,Pik3ca, Atp6v1a,Sesn2,Insr,Slc3a2,Castor1,Flcn, Lpin3,Akt1 | Igf1r,Atp6v1b2,Slc7a5 |
mmu04152 | AMPK signaling pathway | Ulk1,Cab39,Eif4ebp1,Igf1r,Pik3r1,Foxo1, Pik3ca,Irs2,Prkag2,Insr,Foxo3,Ppargc1, Pfkfb3,Akt1 | Igf1r,Prkag2,Ppargc1a |
