Fig. 6
From: Effects of SLC6A8 mutation-induced creatine deficiency on cellular function in fibroblasts
Increased antioxidant enzyme levels in CRT-G561R fibroblasts. (A) Fold changes in the superoxide dismutase 2 (SOD2) and catalase (CAT) levels in the cytosolic fraction of CRT-G561R fibroblasts, compared with those in CRT-WT fibroblasts. (B) Identification of proteins directly interacting with Nrf2 related to antioxidants, using STRING and GO analysis. (C) Fold changes in the levels of five antioxidant proteins identified in the cytosolic fraction of CRT-G561R fibroblasts compared to those in the cytosolic fraction of CRT-WT fibroblasts. Data are presented as mean ± SD (n = 3 independent biological samples). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, significantly different from CRT-WT fibroblasts.
