Fig. 5 | Scientific Reports

Fig. 5

From: Berberine hydrochloride inhibits the proliferation and metastasis of p53 mutant gallbladder Cancer cells by regulating the IL6/STAT3 pathway

Fig. 5The alternative text for this image may have been generated using AI.

Mechanism by which berberine hydrochloride affects GBC cells according to the inflammation array analysis. A/B/C, berberine hydrochloride reduced the concentrations of IL-6, IL-8, and IL-11 in GBC cell supernatants: A, GBC-SD cell line; B, NOZ cell line. D/E/F/G, GO and KEGG enrichment analyses revealed that the cytokine-cytokine receptor interaction pathway, which includes IL-6 and its downstream JAK/STAT signaling pathway, was highly enriched. GBC, gallbladder cancer; NC, negative control (cells were treated with DMSO); BH, berberine hydrochloride (cells were treated with berberine hydrochloride).

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