Table 1 Subtype and characteristics of healthy and breast cancer cell lines used.
Cell line | Subtype | Molecular markers | Incidence | Description |
|---|---|---|---|---|
MCF-12F | Normal basal-epithelial | Does not express receptors like ER | Used as a healthy model in breast cancer studies | Non-tumorigenic* epithelial cell line |
T47D & MCF-7 | luminal A | ER + and/or PR + , HER2 − and low Ki67 | The most common subtype (50–60% of all cases) | Exhibit robust cell-to-cell junctions(36) |
The relapse rate is the lowest in comparison to other types | ||||
The recurrence is mainly in the boneGood prognosis for the patient | ||||
SK-BR-3 | HER2-enriched | HER2/Neu receptor overexpression ER + , PR − and any Ki-67 | 20–30% of all cases of breast cancer | Aggressive biological and clinical behavior |
HCC-1937 | Basal-like B | ER − , PR − and HER2 − | TNBC cell line with stage IIB grade 3 | Derived from primery ductal carcinoma |
Good prognosis for the patient | ||||
MDA-MB-231 | Basal-like | ER − , PR − , HER2 − , CK5/6 + , and/or EGFR + | 80% of basal-like subtype is triple-negative | 15–20% of all cases of breast cancer |
Aggressive clinical behavior | ||||
High rate of metastasis to the brain and lung | ||||
Poor patient prognosis(10) |
