Fig. 1 | Scientific Reports

Fig. 1

From: Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury

Fig. 1

Research flowchart. The molecular structure of amatoxin was retrieved using the PubChem database, and the toxicity of amatoxin was predicted by ProTox-3.0 and ADMETlab 2.0. STITCH and SwissTargetPrediction mined the targets of amatoxin. GeneCards, OMIM, and TTD mined targets related to liver injury. Cytoscape constructs a regulatory network of hepatic injury caused by amatoxin. PPI, GO, and KEGG were used for relevant analysis of targets. Finally, molecular docking technology was used to demonstrate the binding conformation between amatoxin and the core targets.

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