Fig. 5 | Scientific Reports

Fig. 5

From: Proteomic analysis of tumor cell nuclear expulsion reveals significant cell adhesion and RNA binding programs in extracellular chromatin

Fig. 5

Basigin and Integrin A2 in TuNEP mediated tumor outgrowth. (a) Representative images of spheroids from MDA-MB-231-LM3 and parental MDA-MB-231-Par cells cultured for 12 days. (b) Representative images of MDA-MB-231-LM3 spheroids treated with ITGA2 and BSG inhibitors TC-15-I and SP-8356, respectively. (c) Quantification of the size of MDA-MB-231-LM3 derived spheroids treated with TC-15-I and SP-8356 compared to MDA-MB-231-Par spheroids. (d) Quantification of the size of MDA-MB-231-Par spheroids treated with TC-15-I and SP-8356. (e) Luciferase signals from the co-culture of MDA-MB-231-Par cells with TuNEPs or apoDBs that were treated with TC-15-I and SP-8356. CTG assay was used for measuring cell viability through luciferase signal.

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