Table 1 Demographic data of 90 operated intracranial meningiomas in 48 NF2 patients.

Sex (Number of female/male)

26/22

Patients Age at

- first NF2-related sign/symptom

- the time of NF2 diagnosis

- time of surgery

(mean ± SD, range) in years

18 ± 12, 0–55

21 ± 12, 1–55

34 ± 13, 9–73, n = 90

Family History with NF2-related Schwannomatosis

- yes; no

- no information available

number of patients (%)

9 (19%); 37 (77%)

2 (4%)

Tumor Load

- further intracranial meningiomas

- non-vestibular schwannoma (intracranial)

- spinal ependymoma

- spinal extramedullary tumors (meningiomas/schwannomas)

- peripheral nerve tumors (e. g. schwannomas)

number of patients (%)

45 (94%)

21 (44%)

20 (42%)

35 (73%)

22 (46%)

Histolopathological Variants (%, n = numbers)

- transitional

- fibrous

- meningothelial

- psammoatous

- angiomatous

- atypical

- meningothelial and angiomatous

- meningothelial and psammomatous

- no information available

number of tumors (%)

27 (30%)

6 (7%)

31 (34%)

11 (12%)

1 (1%)

10 (11%)

2 (2%)

1 (1%)

1 (1%)

Cranial Region Location Categories

- skull base

- falx

- convexity

- tentorium

- intraorbital

- intraventricular

number of tumors (%)

44 (49%)

16 (18%)

20 (22%)

5 (6%)

3 (3%)

2 (2%)

Tumor Side

- left/right/median in numbers

number of tumors (%)

36 (40%)/46 (51%)/8 (9%)

Resection Extent according to Simpson Grading¹⁵

- I. Complete excision, including dura and bone

- II. Complete excision + supposed reliable coagulation of dural attachment

- III. Complete excision but insufficient dural coagulation or bone excision (not visible on MR, according to surgeon’s opinion)

- IV. Incomplete excision, macroscopic residual visible (on MRI)

- V. Biopsy only

number of tumors (%)

25 (28%)

26 (29%)

16 (18%)

23 (25%)

0