Fig. 4 | Scientific Reports

Fig. 4

From: Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis

Fig. 4

Differential expression patterns of genes related to interferon signaling. The volcano plots show Benjamini-Hochberg (BH) adjusted p-values and logarithmic fold-changes of 595 analyzed genes for each comparison. The horizontal dashed line corresponds to a log-transformed adjusted p-value of 0.05 and all genes above the line are significantly differentially expressed (5% FDR, hierarchical post hoc correction – see Methods for further details). Names of significant genes belonging to the Reactome pathways i) Interferon signaling, ii) Interferon alpha/beta signaling, iii) Antiviral mechanisms by IFN-stimulated genes, iv) ISG15 antiviral mechanism, and v) Negative regulators of DDX58/IFIH1 signaling. See Supp. Information for tabulated gene-to-pathway correspondence.

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