Fig. 1

Effects of IMQ on macroscopic and clinical features of mouse skin after short-term (ST) and long-term (LT) treatments. (A) Representative photographs of ST and LT treatments-induced macroscopic features on mice back skin. (B) Cumulative clinical scores (sum of the scores for erythema (C), desquamation (D) and thickness (E)) after ST and LT treatments with Vaseline or IMQ (ST-Vaseline n = 82, ST-IMQ n = 77, LT-Vaseline n = 66, LT-IMQ n = 64). A Two-Way ANOVA with Bonferroni’s correction was performed to compare each parameter after ST and LT treatments either with Vaseline or IMQ.