Table 4 Univariate Cox regression analysis of factors associated with overall survival and recurrence in elderly HCC patients.

Patient factors/Surgical factors

Age, years

1.027(0.989–1.066)

0.167

0.978(0.941–1.018)

0.274

Gender, male vs. female

0.743(0.489–1.129)

0.164

1.274(0.797–2.039)

0.312

Hepatitis, yes vs. no

1.087(0.767–1.541)

0.640

1.174(0.829–1.663)

0.365

Hypertension yes vs. no

1.024(0.718–1.462)

0.896

0.922(0.651–1.306)

0.648

Type 2 diabetes, yes vs. no

1.352(0.804–2.275)

0.255

0.885(0.491–1.596)

0.685

AFP, > 20ng/mL vs. ≤ 20ng/mL

1.768 (1.272–2.458)

0.001

1.783(1.294–2.457)

< 0.001

ALBI, > 2.63 vs. ≤ 2.63

1.550(1.107–2.171)

0.011

1.401(1.001–1.963)

0.050

Blood transfusion, yes vs. no

2.083(1.297–3.346)

0.002

2.863(1.869–4.385)

< 0.001

Operative bleeding loss, > 800mL vs. ≤ 800mL

2.806(1.685–4.672)

< 0.001

3.168(1.947–5.154)

< 0.001

Resection margin, ≥1 cm vs. < 1 cm

0.749(0.475–1.182)

0.214

0.784(0.502–1.224)

0.284

Inflammation-related marker

PNI, > 53.1 vs. ≤ 53.1

0.543(0.335–0.879)

0.013

0.406(0.244–0.676)

0.001

PLR, > 127.9 vs. ≤ 127.9

1.128(0.802–1.587)

0.490

1.744(1.264–2.408)

0.001

LMR, > 6.7 vs. ≤ 6.7

0.915(0.623–1.343)

0.649

0.708(0.474–1.058)

0.092

NLR, > 2.9 vs. ≤ 2.9

1.378(0.962–1.973)

0.080

1.637(1.161–2.309)

0.005

SII, > 696.2 vs. ≤ 696.2

1.415(0.853–2.348)

0.179

2.337(1.510–3.616)

< 0.001

Tumor factors

Tumor size, ≥5 cm vs. < 5 cm

2.132(1.470–3.091)

< 0.001

2.948(2.030–4.280)

< 0.001

Tumor number, multiple vs. solitary

1.507(1.023–2.220)

0.038

2.746(1.934–3.899)

< 0.001

Microvascular invasion, presence vs. absence

1.837(1.289–2.617)

0.001

1.960(1.391–2.763)

< 0.001

Edmondson-Steiner grade, III-IV vs. I-II

2.147(1.295–3.562)

0.003

2.084(1.274–3.409)

< 0.001

Liver cirrhosis, presence vs. absence

1.080(0.773–1.509)

0.653

1.174(0.842–1.637)

0.345