Fig. 3
From: Cooperative role of MDSCs and Tregs in alum-induced alloimmune tolerance in corneal transplantation
Alum-induced MDSCs improve corneal allograft survival. (A) Alum-treated mice showed significantly prolonged corneal allograft survival compared to untreated allogeneic controls. Approximately 50% of the alum-treated recipients maintained long-term graft clarity, while all allogeneic controls experienced complete rejection within 15 days (B) Comparison of graft survival in PBS-treated, alum-treated, MDSC-treated, and syngeneic control groups. Alum treatment significantly improved graft survival compared to PBS and MDSC groups, while MDSC transfer alone resulted in moderate prolongation. Syngeneic grafts remained fully accepted without signs of rejection throughout the observation period. Statistical significance was assessed using the log-rank test. ***p < 0.001;**p < 0.01; *p < 0.05.
