Fig. 6 | Scientific Reports

Fig. 6

From: Association of Hsa_circ_0059511 with the sensitivity of the temozolomide chemotherapeutic treatment in human glioma cells

Fig. 6

In vivo validation of circ0059511 knockdown effects on TMZ sensitivity and FZD6 regulation. (A) The U251 cells-xenograft tumors formation in shRNA NC plus DMSO, shRNA NC plus TMZ treatment, circ-0059511 stably knock down plus DMSO, and circ-0059511 stably knock down plus TMZ treatment groups. (B) H&E staining of tumor sections confirming glioblastoma histopathology across groups. (C) IHC analysis demonstrating FZD6 expression patterns (brown staining) in representative tumor sections. (D, E) The tumor growth volume and weight of different treated groups mentioned-above.

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