Fig. 5
From: Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen
Docking of cephalosporin C in TDP1 based on the structure of the TDP1-XZ634p complex (PDB code: 6W7K). (A) Structure of TDP1 noncovalently bound to cephalosporin C (carbon bonds in yellow) within the DNA substrate binding pocket (carbon bonds in grey). Hydrogen bonds are shown as cyan dashed lines; (B) Structure of TDP1 covalently bound cephalosporin C (carbon bonds in yellow) within the DNA substrate binding pocket (carbon bonds in grey). Hydrogen bonds are shown as cyan dashed lines.
