Fig. 3 | Scientific Reports

Fig. 3

From: Telomerase activity in T-cells as a functional test for pathogenicity assessment of novel genetic variants in telomere biology disorders

Fig. 3

ΔCT and telomerase activity (TA) adjusted for S-phase fraction (SPF) and plotted against age. Controls are represented as white circles and TBD patients as grey circles. ***Corresponds to p-values < 0.001 (Mann-Whitney U test). (A) Adjusted ΔCT in controls and TBD plotted against age. The black solid line represents the mean of the normal controls and the black dashed lines represent standard deviation ± 1, ±2, and ± 3. (B) Boxplots of adjusted ΔCT in controls and TBD patients. The black solid line represents the median. (C) Adjusted TA in controls and TBD plotted against age. The black solid line represents the mean adjusted TA (converted from the mean ΔCT) of the normal controls and the black dashed lines represent standard deviation ± 1, ±2, and ± 3 from the mean (converted from the ΔCT standard deviations). (D) Boxplots of adjusted TA in controls and TBD. The black solid line represents the median.

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