Table 2 Multivariable Cox model for overall survival in patients whose baseline and disease characteristics are known (n = 443).
OS univariate HR (95% CI) | p–value | OS multivariate HR (95% CI) | p–value | |
|---|---|---|---|---|
Age | 1.04 (1.03–1.05) | < 0.001 | 1.06 (1.04–1.07) | < 0.001 |
Age over 60 years at diagnosis | 2.49 (2.08–3.00) | < 0.001 | 1.61 (1.08–2.40) | 0,019 |
Male gender | 1.10 (0.95–1.28) | 0.21 | 1.27 (1.01–1.60) | 0.041 |
B-symptoms | 1.41 (1.13–1.75) | 0.002 | 1.19 (0.94–1.51) | 0.156 |
Ann Arbor III-IV | 2.00 (1.54–2.61) | < 0.001 | 1.85 (1.34–2.56) | < 0.001 |
Extranodal involvement | 1.77 (1.38–2.25) | < 0.001 | 1.13 (0.27–1.57) | 0.434 |
BM | 1.39 (1.09–1.78) | 0.01 | 1.26 (0.93–1.72) | 0.137 |
Spleen | 1.01 (0.78–1.31) | 0.94 | not included | |
GI | 2.24 (1.72–2.92) | < 0.001 | 1.52 (0.85–2.70) | 0.16 |
Skin | 1.07 (0.81–1.42) | 0.64 | not included | |
Lung | 1.43 (1.02–2.00) | 0.05 | 1.43 (0.97–2.11) | 0.074 |
CNS | 2.67 (1.26–5.65) | 0.027 | not included | |
Liver | 1.13 (0.75–1.71) | 0.57 | not included | |
Bone | 0.54 (0.31–0.94) | 0.016 | 0.68 (0.38–1.21) | 0.19 |
Kidney | 2.94 (1.21–7.13) | 0.042 | 2.77 (1.01–7.56) | 0.05 |
PTCL NOS | 1.00 reference | 1.00 reference | ||
ALCL ALK- | 0.63 (0.48–0.82) | < 0.001 | 0.88 (0.62–1.25) | 0.48 |
ALCL ALK + | 0.11 (0.06–0.21) | < 0.001 | 0.31 (0.12–0.77) | 0.011 |
ALCL ALK unknown | 0.97 (0.67–1.39) | 0.862 | 1.54 (0.73–3.22) | 0.26 |
AITL | 0.86 (0.71–1.03) | 0.09 | 0.62 (0.47–0.82) | 0.001 |
EATL | 1.31 (1.03–1.68) | 0.033 | 1.59 (0.85–2.98) | 0.151 |
ENKTCL | 0.78 (0.48–1.26) | 0.29 | 1.91 (1.03–3.56) | 0.041 |
HSCTL | 1.87 (0.77–4.52) | 0.21 | 4.09 (1.46–11.47) | 0.007 |
