Fig. 1
From: Immune cell subsets in autoimmune polyendocrine syndrome type I
Unsupervised analysis of human whole blood-derived mass cytometry (CyTOF) normalized data on autoimmune polyendocrine syndrome type I (APS-I) patients and healthy controls (HC) for dataset 1. Downsampled CD45 + CD66b- cells. (A) UMAP plots including eight clusters for APS-I patients and healthy controls. The clusters are manually annotated based on the marker heatmap in Fig. S6. (B) Boxplot on cell frequency in each cluster for APS-I patients and healthy controls. (C) MDS-plot for CD45 + CD66b- cells with colours representing the two cohorts of interest. Statistical tests were performed by the EdgeR and limma R packages. Tc cytotoxic T cells, Th T helper cells, gdT gammadelta T cells, DC dendritic cells, pDC plasmacytoid DC, NK natural killer cells, Mis Miscellaneous.
