Fig. 5 | Scientific Reports

Fig. 5

From: Comparative analysis of clinical features, methylation and immune microenvironment in pediatric and adult papillary craniopharyngiomas: results from a multicenter study

Fig. 5

Expression of S100A8/A9 and MPO in PPCP and APCP. (A, B) Ubiquitous S100A8/A9 expression in tumor parenchyma and stroma. (C, D) MPO detection in both subtypes. (E) Comparable parenchymal S100A8/A9 between groups. (F) PPCP exhibited significantly higher S100A8/A9 expression in stromal cells compared to APCP (t = 11.92, p < 0.01) (G, H) PPCP shows elevated MPO in both parenchyma (t = 7.718, P < 0.01) and stroma (t = 2.879, P < 0.01). (I, J) No significant correlations between MPO parenchyma and S100A8/A9 stroma in either subtype. (K) Immunofluorescence validation of S100A8 spatial distribution. (L, O) Lack of stromal MPO-S100A8/A9 correlations across compartments (all P > 0.05).

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