Table 1 Targets of salidroside for alleviating diabetic amyotrophy.
From: Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit apoptosis
Serial number | Gene symbol | Uniprot ID | Protein name |
|---|---|---|---|
1 | PPARG | P37231 | Peroxisome proliferator-activated receptor gamma |
2 | ACE | P12821 | Angiotensin-converting enzyme |
3 | TNF | A0A0G2YPN5 | Tumor necrosis factor |
4 | AKR1B1 | P15121 | Aldo–keto reductase family 1 member B1 |
5 | ATM | Q13315 | Serine-protein kinase ATM |
6 | SLC5A2 | P31639 | Sodium/glucose cotransporter 2 |
7 | MMP9 | P14780 | Matrix metalloproteinase-9 |
8 | REN | P00797 | Renin |
9 | NR3C1 | P04150 | Glucocorticoid receptor |
10 | HMGCR | P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
11 | GPR35 | Q9HC97 | G-protein coupled receptor 35 |
12 | VCP | P55072 | Valosin-Containing Protein |
13 | CNR1 | P21554 | Cannabinoid receptor 1 |
14 | BRAF | P15056 | Serine/threonine-protein kinase B-raf |
15 | SLC5A1 | P13866 | Sodium/glucose cotransporter 1 |
16 | AGTR2 | P50052 | Type-2 angiotensin II receptor |
17 | GLO1 | Q04760 | Lactoylglutathione lyase |
18 | BCHE | P06276 | Cholinesterase |
19 | ACHE | P22303 | Acetylcholinesterase |
20 | CASP3 | P42574 | Caspase-3 |
21 | CTSB | P07858 | Cathepsin B |
22 | HSP90AA1 | P07900 | Heat shock protein HSP 90-alpha |
23 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src |
24 | BCL2 | P10415 | Apoptosis regulator Bcl-2 |
25 | XDH | P47989 | Xanthine dehydrogenase/oxidase |
26 | APP | P05067 | Amyloid-beta precursor protein |
27 | TRPV1 | Q8NER1 | Transient receptor potential cation channel subfamily V member 1 |
28 | KRAS | P01116 | GTPase KRas |
29 | NQO1 | P15559 | NAD(P)H dehydrogenase quinone 1 |
30 | CAPN1 | P07384 | Calpain-1 catalytic subunit |
31 | CACNA1C | Q13936 | Voltage-dependent L-type calcium channel subunit alpha-1C |
32 | CASP1 | P29466 | Caspase-1 |
33 | KEAP1 | Q14145 | Kelch-like ECH-associated protein 1 |
34 | THRB | P10828 | Thyroid hormone receptor beta |
35 | CASP8 | Q14790 | Caspase-8 |
36 | SIGMAR1 | Q99720 | Sigma non-opioid intracellular receptor 1 |
37 | EPHX1 | P07099 | Epoxide hydrolase 1 |
38 | MAPK3 | L7RXH5 | Mitogen-activated protein kinase |
39 | PDE8B | O95263 | High affinity cAMP-specific and IBMX-insensitive 3’,5'-cyclic phosphodiesterase 8B |
40 | ELANE | P08246 | Neutrophil elastase |
41 | TDP2 | O95551 | Tyrosyl-DNA phosphodiesterase 2 |
42 | HDAC6 | Q9UBN7 | Histone deacetylase 6 |
43 | CFD | P00746 | Complement factor D |
44 | BCL2L1 | Q07817 | Bcl-2-like protein 1 |
45 | CHRNB4 | P30926 | Neuronal acetylcholine receptor subunit beta-4 |
46 | BACE1 | P56817 | Beta-secretase 1 |
47 | IDH1 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic |
48 | DRD3 | P35462 | D(3) dopamine receptor |
49 | HDAC1 | Q13547 | Histone deacetylase 1 |
50 | SIRT2 | Q8IXJ6 | NAD-dependent protein deacetylase sirtuin-2 |
51 | KDM5C | P41229 | Lysine-specific demethylase 5C |
52 | SLC6A3 | Q01959 | Sodium-dependent dopamine transporter |
53 | SLC1A2 | P43004 | Excitatory amino acid transporter 2 |
54 | DHFR | P00374 | Dihydrofolate reductase |
55 | FYN | P06241 | Tyrosine-protein kinase Fyn |
56 | ADK | P55263 | Adenosine kinase |
57 | TOP1 | P11387 | DNA topoisomerase 1 |
58 | USP7 | Q93009 | Ubiquitin carboxyl-terminal hydrolase 7 |
59 | PIN1 | Q13526 | Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 |
60 | ICMT | O60725 | Protein-S-isoprenylcysteine O-methyltransferase |
61 | BRD1 | O95696 | Bromodomain-containing protein 1 |
