Table 4 Mouse bioassay results for white-tailed deer fetal tissues from CWD-positive dams. Cervidized (TgCerPrP−E2265037+/−) mice were intraperitoneally (IP) inoculated with fetal brain (fetuses 5–12 A and 7–6 A) or fetal thymus (6-1B) samples. Terminal mouse brain and spleen tissues were tested in conventional RT-QuIC for amyloid seeding activity. Mock inoculated mice remained free of clinical signs throughout, and tested CWD-negative upon terminal collections in all cohorts. DPI = days post inoculation. # pos/total mice = number CWD-positive/total number inoculated.
From: Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations
Location | Fetal tissues in bioassay | No. pos/total mice | DPI |
|---|---|---|---|
Arkansas | 5–12 A Brain | 1/6 | 213 ± 89.5 |
Tennessee | 6-1B Thymus | 6/8 | 325 ± 44.3 |
West Virginia | 7–6 A Brain | 5/5 | 270 ± 26.2 |
Negatives | Brain | 0/6 | |
Thymus | 0/8 | ||
