Fig. 4
From: Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity
Tofo induces Pax7 and MyoG gene expressions through FAPs to express follistatin (Fst) and promote healing upon CTX-induced skeletal muscle injury. (A–C) Myogenesis-related Pax7, Myf5, and MyoG gene expression (NC = 7; HFD+Saline = 7; HFD+Tofo = 7). (D, E) FAPs related gene markers Pdgfrα, Dpp4 (NC = 7; HFD+Saline = 7; HFD+Tofo = 7). (F–H) Activated FAPs-related genes Wisp1, Fst, and Fstl1 (NC = 7; HFD+Saline = 7; HFD+Tofo = 7). (I) Western blot analysis of AMPKα (Th172)-phosphorylation in skeletal muscle TA after one week of CTX-induced injury (left), and the quantification of immunoblotting analysis of p-AMPKα normalized with AMPK (right) (NC = 3; HFD+Saline = 3; HFD+Tofo = 3). Data represents mean ± SEM. Statistical analysis was performed using one-way ANOVA. (*p < 0.05, **p < 0.01, ***p < 0.001).
