Fig. 2
From: Comparative and pharmacological investigation of bEVs from eight Lactobacillales strains
Identification of putative indications for bEVs. A. Hierarchical clustering of the bEV-induced transcriptome. The dendrogram presents clustering results inferred from the Euclidean distance between bEV-induced transcriptomes. B. bEV-induced DEGs. Each stacked bar represents the number of genes upregulated (red) or downregulated (green) by bEVs. Fold change cutoff = 1.5. C. KEGG pathway enrichment analysis. The heatmap depicts the log-transformed p values of KEGG pathways enriched with bEV-induced DEGs. D. CMap analysis of bEVs. The stacked bar shows the number of drugs classified at ATC level 1 connected to each bEV. The indications of ATC level 1 drugs are presented by color on the right side of the graph. E. Hierarchical clustering of bEV-connected drugs. The heatmap represents the connectivity scores between bEVs and drugs, ranging from 99.98 (red) to -97.09 (blue). Drugs in black text indicate skin health therapeutics, and drugs in blue text indicate nonskin health therapeutics.
