Table 2 Larvicidal activity of the precursor compound 1a and twelve thiophene-isoquinolinone derivatives against third-instar Culex pipiens larvae, compared to chlorpyrifos, at 24 h post-treatment. Data are expressed as LC₅₀ values with 95% confidence intervals.

From: Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens

Compound No.

LC50 (µg/mL)

r2

χ2cal./Tab.(7.8)

χ2 P-value

Toxicity index

1a

0.004

0.78

0.9

0.88

100

2

14

0.97

3.7

0.49

0.028

3

27

0.95

7.7

0.08

0.0141

5a

25.3

0.96

6.5

0.21

0.015

5b

28

0.98

7.1

0.19

0.0142

5c

24.6

0.95

6

0.23

0.016

5d

24.1

0.96

7.2

0.11

0.0165

5e

16.3

0.97

7.3

0.07

0.024

5f

0.3

0.97

0.2

0.86

1.33

6

0.1

0.95

0.4

0.91

4

7

1.85

0.95

5.1

0.29

0.21

8

23.8

0.95

7.4

0.18

0.0168

9

16.4

0.97

4.7

0.66

0.0243

Chlorpyrifos

293.8

0.98

2.2

0.92

0.001

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