Fig. 21
UMAP Projection and Cell-Type Annotation. UMAP projection of single-cell RNA-seq data showing cluster distributions of major immune cell types and subpopulations. Cells were annotated using a majority-voting strategy: each cell received multiple candidate labels which were consolidated via standardized nomenclature and statistical consensus. Final classification identified five myeloid subsets—Classical Monocytes, Non-classical Monocytes, DC2 (type 2 dendritic cells), pDC (plasmacytoid dendritic cells), and Neutrophils—four lymphoid subsets—Tem/Effector Helper T cells, Tcm/Naïve Cytotoxic T cells, MAIT (mucosal-associated invariant T cells), and CD16⁺ NK cells—and additional populations including Megakaryocytes/Platelets, Plasmablasts, and Late Erythroid cells.
