Fig. 22 | Scientific Reports

Fig. 22

From: Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide’s multi-target mechanisms in sepsis

Fig. 22

Differential Expression of Ani HBr–Associated Genes Across Cell Types. Wilcoxon rank-sum tests were performed on 30 genes intersecting Ani HBr targets and sepsis biomarkers to compare expression across annotated cell populations. ELANE is significantly upregulated in neutrophils from sepsis patients, consistent with its pro-inflammatory role and involvement in NET formation. In contrast, CCL5 shows broad upregulation across multiple lineages—including Tem/Temra cytotoxic T cells, CD16⁺ NK cells, and megakaryocyte/platelet clusters—highlighting its central function in chemotactic recruitment. Dot size represents the percentage of cells within each group expressing the gene, and dot color intensity (red) indicates mean expression level.

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