Fig. 3 | Scientific Reports

Fig. 3

From: Integrative network pharmacology and multi-omics reveal anisodamine hydrobromide’s multi-target mechanisms in sepsis

Fig. 3

Intersection and Expression Analysis of Ani HBr Targets, GeneCards Sepsis Genes, and DEGs (A) Venn diagram of Ani HBr targets (blue), GeneCards–derived sepsis genes (yellow), and DEGs from GSE65682 (green), identifying 30 overlapping genes, including STAT1, PDE4B, and CFD. (B) Heatmap of the 30 intersecting genes across healthy controls (left), non-survivor sepsis patients (middle), and survivor sepsis patients (right); red and green indicate high and low expression, respectively. (C) Pairwise correlation analysis among key genes: each tile represents the correlation between two genes, with red indicating positive correlation and blue indicating negative correlation; color intensity corresponds to the strength of the correlation (e.g., ELANE–CTSG and MMP9–ARG1 show strong positive associations, whereas AKR1B1–MAPK14 and AKR1B1–TLR8 are negatively correlated).

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