Table 3 Comparison of log2-fold change between cases and controls for genes associated with clinical traits preceding lipid-regulating drug usage.
Phenotype | FDR > 5% | FDR < 5% | ∆ LFC | P-value |
|---|---|---|---|---|
Cardiovascular | ||||
ECG P axis | 20,171 | 242 | 0.0074 | 2.19 × 10−4 |
Dual x-ray absorptiometry | ||||
All tissue in gynoid region | 18,414 | 1999 | 0.0066 | 6.77 × 10−18 |
Area of fat inside abdominal cavity | 8431 | 11,982 | 0.0040 | 3.25 × 10−22 |
Fat tissue in trunk region | 7712 | 12,701 | 0.0022 | 9.84 × 10−8 |
Lean tissue in right leg region | 19,276 | 1137 | 0.0084 | 4.32 × 10−17 |
Mass in right leg region | 15,197 | 5216 | 0.0060 | 4.56 × 10−33 |
% of fat in android region | 6153 | 14,260 | 0.0017 | 7.68 × 10−5 |
% of fat in visceral region | 6097 | 14,316 | 0.0015 | 3.51 × 10−4 |
% of fat in visceral/gynoid region | 5423 | 14,990 | 0.0009 | 2.18 × 10−2 |
% of fat tissue in trunk region | 6036 | 14,377 | 0.0020 | 2.73 × 10−6 |
% of total body mass that is fat | 10,385 | 10,028 | 0.0028 | 6.08 × 10−12 |
Trunk fat | 6485 | 13,928 | 0.0016 | 1.88 × 10−4 |
∆ % of fat in visceral/android region | 20,046 | 367 | 0.019 | 8.22 × 10−21 |
Lipid profiles | ||||
Apolipoprotein B | 18,343 | 2070 | 0.022 | 1.01 × 10−127 |
High density lipoprotein | 9883 | 10,530 | 0.0022 | 2.74 × 10−8 |
Serum triglycerides level | 12,214 | 8199 | 0.0049 | 1.55 × 10−29 |
