Table 2 Univariate analysis of US and CEUS characteristics.

From: Perfluorobutane CEUS for early-stage cervical lymphoma: diagnostic value of the postvascular phase starfield sign

Modality and feature

Description

Lymphoma

Benign LNs

P-value

US

 Shape

Round/oval

16

22

0.06

Irregular

7

2

 

 Smooth edge

Yes

21

23

0.61

No

2

1

 

 Echogenicity

Hypo-echoic

22

23

1.00

Mixed-echoic

1

1

 

 Cystic degeneration

Yes

2

1

0.61

No

21

23

 

 Homogeneous echo

Yes

12

19

0.06

No

11

5

 

 Hilum

Yes

9

14

0.19

No

14

10

 

 Portal blood flow

Yes

9

16

0.06

No

14

8

 

CEUS

 Vascular phase

  Perfusion pattern

Centripetal

17

11

0.02

Centrifugal

2

11

 

Diffuse

4

2

 

  Enhancement intensity

Hyperenhancement

15

20

0.09

Isoenhancement

1

4

 

Hypoenhancement

7

0

 

  Homogeneity

Homogeneous

22

23

0.71

Heterogeneous

1

1

 

  Postvascular phase

Sunburst sign

2

17

 < 0.01

Starfield sign

21

4

 

Black hole sign

0

3

 
  1. US: ultrasound, CEUS: contrast-enhanced ultrasound, LN = lymph node, Categorical variables were analyzed using Pearson’s chi-squared test and Fisher’s exact test.