Fig. 8 | Scientific Reports

Fig. 8

From: Molecular self-assembly mediates the flocculation activity of benzimidazole derivatives against E. coli

Fig. 8

(a) Longitudinal relaxivity values (r1, 60 MHz, 37 °C) measured for liposomes in the presence of DMSO (negative control), compound 8 (59 µM), and Triton X-100 (positive control) under conditions of [PO43−] = 2.8 mM and a compound-to-lipid ratio of ≅ 1:50. (b) Dynamic light scattering (DLS) analysis of paramagnetic liposomal solution after 30 min of treatment with 59 µM of compound 8. (c–e) Snapshots from molecular dynamics simulations of a DPPC/DPPG membrane model in the presence of compound 8, where the ligand was initially positioned (c) in the aqueous medium (system (I)), (d) at the aqueous medium-lipid bilayer interface (system (II)), and (e) within the lipid bilayer (system (III)).

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