Fig. 8 | Scientific Reports

Fig. 8

From: Molecular self-assembly mediates the flocculation activity of benzimidazole derivatives against E. coli

Fig. 8The alternative text for this image may have been generated using AI.

(a) Longitudinal relaxivity values (r1, 60 MHz, 37 °C) measured for liposomes in the presence of DMSO (negative control), compound 8 (59 µM), and Triton X-100 (positive control) under conditions of [PO43−] = 2.8 mM and a compound-to-lipid ratio of ≅ 1:50. (b) Dynamic light scattering (DLS) analysis of paramagnetic liposomal solution after 30 min of treatment with 59 µM of compound 8. (c–e) Snapshots from molecular dynamics simulations of a DPPC/DPPG membrane model in the presence of compound 8, where the ligand was initially positioned (c) in the aqueous medium (system (I)), (d) at the aqueous medium-lipid bilayer interface (system (II)), and (e) within the lipid bilayer (system (III)).

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