Fig. 5

Plasma concentration–time profile of sulfasalazine [A (0–24 h; semi-log scale) and B (0–6 h; linear scale)], 3,4′-dimethoxyflavone (C), and 3,6,3′,4′-tetramethoxyflavone (D). Rats were orally administered sulfasalazine (2 mg/kg) without or with 3,4′-dimethoxyflavone and 3,6,3′,4′-tetramethoxyflavone (5 mg/kg). Data are expressed as the mean ± SD (n = 5).