Table 1 Clinical and demographic characteristics at baseline and at 3, 6, and 9 months post-bariatric surgery.

From: Multi-omics analysis of bariatric surgery’s impact on type 2 diabetes and prediabetes

 

Pre–surgery

3–months post–surgery

6–months post–surgery

9–months post–surgery

p–value

(9–months vs. baseline)

Demographic parameters

 Age (years)

35.6 ± 8.87

–

–

–

0.887†

 Male/Female

9.0/10 (47%/53%)

–

–

–

0.934‡

 Weight (kg)

118.8 ± 19.45

98.34 ± 11.66

90.15 ± 13.77

87.6 ± 13.09

p < 0.0001*

 BMI (kg/m2)

42.27 ± 5.57

34.42 ± 2.36

31.97 ± 2.354

30.91 ± 2.42

p < 0.0001*

 EBWL (%)

–

45.57 ± 25.41

62.92 ± 13.01

68.25 ± 13.85

–

 TWL (%)

–

16.14 ± 4.88

24.6 ± 5.58

26.51 ± 5.04

–

Blood pressure

 Systolic BP (mmHg)

129.2 ± 14.89

126.2 ± 10.94

123.17 ± 11.99

105 ± 9.839

0.0014*

 Diastolic BP (mmHg)

79.79 ± 9.65

73.8 ± 4.438

75.83 ± 8.75

66.83 ± 9.020

0.0022*

Lipid profile (mmol/L)

 Total cholesterol

4.91 ± 1.34

4.52 ± 0.765

4.589 ± 0.483

4.71 ± 0.558

0.441

 LDL cholesterol

3.30 ± 1.18

2.923 ± 0.8

3.119 ± 0.483

3.105 ± 0.576

0.3598

 HDL cholesterol

1.29 ± 0.41

1.304 ± 0.291

1.344 ± 0.360

1.503 ± 0.327

0.2968

 Non–HDL cholesterol

3.68 ± 1.35

3.51 ± 0.974

3.243 ± 0.509

3.2 ± 0.648

0.1782

 Triglycerides

1.57 ± 1.21

1.176 ± 0.359

0.999 ± 0.312

0.922 ± 0.273

0.0382*

Biochemistry

 HbA1C (%)

6.23 ± 1.07

5.65 ± 0.838

5.517 ± 0.685

5.388 ± 0.591

0.0464*

 Hemoglobin (g/L)

133.1 ± 13.40

135.3 ± 14.57

129.43 ± 11.18

127.9 ± 15.27

0.2942

 Glucose (mmol/L)

6.64 ± 1.88

5.029 ± 0.468

5.025 ± 0.443

4.85 ± 0.45

0.0466*

 Creatinine (µmol/L)

61.53 ± 16.34

60.43 ± 11.12

56.75 ± 7.066

58.25 ± 10.39

0.9314

 Ferritin (mcg/L)

109.55 ± 116.269

194.5 ± 0.778

131.3 ± 163.7

109.2 ± 108.6

0.3444

 Iron (µmol/L)

10.39 ± 4.16

13.07 ± 4.192

12.91 ± 4.634

16.43 ± 5.087

0.0058*

 Vitamin B12 (pmol/L)

294.69 ± 119.09

603.7 ± 151.7

501.1 ± 178.7

423.6 ± 178.9

0.5658

 Vitamin B1 (nmol/L)

102.4 ± 25.05

89.43 ± 21.49

114.4 ± 23.44

115.8 ± 29.27

0.0852*

 Vitamin D (nmol/L)

58.62 ± 31.15

67.8 ± 12.16

56.9 ± 4.384

58.2 ± 10.75

0.8648

 Albumin (g/L)

54.95 ± 59.93

41.29 ± 4.309

42.0 ± 2.38

43 ± 2.778

0.3798

 Neutrophils (× 109/L)

4.69 ± 1.77

3.733 ± 1.381

3.136 ± 1.306

2.963 ± 0.931

0.0152*

 Transferrin (g/L)

2.66 ± 0.357

2.2 ± 0.265

2.50 ± 0.456

2.529 ± 0.475

1.0

 TSH (mIU/L)

2.627 ± 2.99

1.575 ± 0.981

1.446 ± 0.616

1.613 ± 0.936

0.5602

  1. Data are presented as the mean ± standard deviation (SD) or as counts (n), and age is presented as mean ± SD. BMI body mass index, EBWL Excess body weight loss, %TWL Percent total weight loss, BP blood pressure, LDL Low-density lipoprotein, HDL High-density lipoprotein, HbA1c glycosylated hemoglobin, TSH thyroid stimulating hormone.
  2. p-value was calculated using a paired t-test with a two-tailed approach.
  3. *p ≤ 0.05 was considered significant.
  4. †: One-way ANOVA test.
  5. ‡: Chi-squared test.
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