Table 1 Screening of candidate CpG sites for urothelial carcinoma detection.
gene ID | probe ID | UC patients (10) | benign urological diseases (5) | Healthy control (5) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Tumor | paratumor | Urine | Urine | Urine | |||||||
positive % | ΔCt value | positive % | ΔCt value | positive % | Ct value | positive % | Ct value | positive % | Ct value | ||
HIST1H4F | cg10723962 | 50 | 5.98(4.68–6.97) | 20 | 11.14(7.99–15.84) | 40 | 35.67(33.45–36.77) | 0 | / | 20 | 35.93(34.21–37.65) |
cg21425842, cg08260959 | 100 | 5.68(3.13–8.28) | 100 | 10.17(7.26–20.64) | 80 | 32.79(31.10-34.82) | 0 | / | 0 | / | |
SOX1-OT | cg11437784 | 40 | 4.55(2.22–6.15) | 10 | 7.24 | 30 | 34.19(32.41–36.51) | 0 | / | 0 | / |
cg15736169, cg03898631 | 100 | 4.06(1.92–8.09) | 100 | 7.80(5.24–11.38) | 80 | 32.62(31.72–35.16) | 0 | / | 0 | / | |
NRN1 | cg11564981 | 70 | 3.85(2.60–5.30) | 20 | 6.28(5.55-7.00) | 50 | 34.64(32.55–36.14) | 0 | / | 0 | / |
POU4F2 | cg02610222 | 30 | 8.54(6.57–10.87) | 0 | / | 20 | 37.08(36.51–37.65) | 0 | / | 0 | / |
cg24199834 | 60 | 5.76(3.11–10.79) | 30 | 8.86(8.44–9.14) | 40 | 33.82(31.66–35.59) | 0 | / | 0 | / | |
Vim | cg11973177 | 80 | 6.87(5.27–8.64) | 30 | 9.98(5.44–13.63) | 80 | 31.58(29.74–36.46) | 0 | / | 30 | 33.89(31.27–35.27) |
cg21425842 | 100 | 4.11(2.14–5.70) | 100 | 7.27(4.97–14.14) | 70 | 31.66(30.02–33.96) | 60 | 33.13(31.21–35.64) | 60 | 33.01(30.98–35.01) | |
Onecut2 | cg02250594 | 100 | 7.49(4.42–10.97) | 40 | 9.74(7.87–12.54) | 80 | 29.16(24.82–38.34) | 20 | 33.14(32.96–33.32) | 20 | 34.03(33.19–34.87) |
cg23757446 | 100 | 4.63(2.84–8.09) | 100 | 8.94(6.01–13.05) | 60 | 35.47(33.16–37.12) | 40 | 36.97(34.45–38.87) | 40 | 36.87(34.33–38.24) | |
Twist1 | cg26818735, cg26312150 | 60 | 3.83(1.84–6.38) | 20 | 7.01(5.32–6.88) | 30 | 39.92(39.50-40.34) | 0 | / | 0 | / |
