Fig. 4 | Scientific Reports

Fig. 4

From: Frem2 knockout mice exhibit Fraser syndrome phenotypes and neonatal lethality due to bilateral renal agenesis

Fig. 4

Renal agenesis in Frem2-KO pups. Macroscopic images of P0 pups show kidneys (K), adrenal glands (AD), and urinary bladder (UB) present in a Frem2+/+ pup (A), and kidneys and an inconspicuous urinary bladder in a Frem2-/- pup (B). Hematoxylin and eosin-stained parasagittal sections of a Frem2+/+ (left column) and a Frem2-/- (right column) P0 pup show organs present to the left (C, D) and right (E, F) of the spinal cord. Locations of the deflated urinary bladders are labeled with asterisks. Sections are from similar regions to compare the presence and morphology of organs. Scale bars: A, B; 1 mm, C–F; 3 mm. Labels: AD adrenal glands, K kidney, H heart, LV liver, LUN lung, I intestines, S stomach, UB urinary bladder.

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