Fig. 1 | Scientific Reports

Fig. 1

From: Anti-protein arginine methyltransferase 5 (PRMT5) antibodies is associated with interstitial lung disease in rheumatoid arthritis

Fig. 1

Association of anti-PRMT5 antibodies with systemic sclerosis (SSc) and rheumatoid arthritis (RA). Serum levels of the anti-PRMT5 antibodies were determined using a double-antigen sandwich ELISA. Seropositivity for the anti-PRMT5 antibodies was defined as OD 450 nm values above the 99th percentile of the upper limit observed in healthy controls (HC). (A) Serum levels of anti-PRMT5 antibodies in healthy controls (n = 31), patients with RA (n = 87) and patients with SSc (n = 33). (B) Receiver operating characteristic (ROC) curve analyses assessing the diagnostic performance of anti-PRMT5 antibodies in distinguishing RA and SSc patients from healthy controls. The area under the curve (AUC) and corresponding p-values are indicated. (C) Proportion of individuals seropositive for anti-PRMT5 antibodies in healthy controls, RA, and SSc cohorts. Statistical significance: *p < 0.05, **p < 0.01. p < 0.001 and ****p < 0.0001.

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