Fig. 11 | Scientific Reports

Fig. 11

From: Discovery of novel SND1 inhibitors by in silico–based molecular docking and dynamics simulation methods for managing hepatocellular carcinoma

Fig. 11

Bar chart showing the residue per binding energy across TOP1, TOP2, and STD–bound SND1 complexes: (A) 0 ns, (B) 150 ns, and (C) 300 ns. Abbreviation: SND1 = Staphylococcal nuclease domain-containing protein 1; TOP1 = [4–(5,6,7,8–tetrahydro–4 H–cyclohepta[c][1,2]oxazol–3–yl)piperidin–1–yl]–[4–(trifluoromethyl)phenyl]methanone; TOP2 = 1–[2–hydroxy–2–(1–methylsulfonyl–3,4–dihydro–2 H–quinolin–6–yl)ethyl]–4–(4–methylphenyl)piperidin–4–ol. Figures were generated by using OriginPro 8.5.

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