Table 1 Comparison of clinical characteristics between the DVT and non-DVT groups.

From: Integrating 7-day D-dimer exposure into deep vein thrombosis risk prediction after gastrointestinal surgery

Characteristics

Subgroup

non-DVT (n = 413)

DVT (n = 112)

P value

7dDDE (µg/mL·day)

 

17.44 [11.13, 26.89]

28.40 [19.73, 41.06]

 < 0.001

Age (years)

 

66.00 [58.00, 70.00]

69.00 [62.00, 73.00]

0.003

BMI (kg/m2)

 

22.50 [20.30, 25.10]

22.70 [19.88, 24.20]

0.126

Gender

   

1

Female

158 (38.3)

43 (38.4)

 

Male

255 (61.7)

69 (61.6)

 

ASA Score

   

0.52

I

11 (2.7)

2 (1.8)

 

II

270 (65.4)

72 (64.3)

 

III

130 (31.5)

36 (32.1)

 

IVi

2 (0.5)

2 (1.8)

 

Anesthesia method

   

0.871

GA with Double-Lumen Tube + Epidural

8 (1.9)

2 (1.8)

 

GA with Intubation

90 (21.8)

21 (18.8)

 

GA with Intubation + Epidural

289 (70.0)

80 (71.4)

 

GA with Intubation + Nerve Block

20 (4.8)

6 (5.4)

 

others

6 (1.5)

3 (2.7)

 

Smoking history

   

0.225

No

397 (96.1)

104 (92.9)

 

Yes

16 (3.9)

8 (7.1)

 

Past surgical history

   

0.55

No

291 (70.5)

75 (67.0)

 

Yes

122 (29.5)

37 (33.0)

 

History of cardiovascular disease

   

1

No

389 (94.2)

105 (93.8)

 

Yes

24 (5.8)

7 (6.2)

 

History of malignancy

   

0.959

No

388 (93.9)

106 (94.6)

 

Yes

25 (6.1)

6 (5.4)

 

History of diabetes

   

1

No

341 (82.6)

92 (82.1)

 

Yes

72 (17.4)

20 (17.9)

 

History of hypertension

   

0.752

No

289 (70.0)

76 (67.9)

 

Yes

124 (30.0)

36 (32.1)

 

History of fracture

   

0.857

No

406 (98.3)

111 (99.1)

 

Yes

7 (1.7)

1 (0.9)

 

Temperature (℃)

 

36.50 [36.40, 36.50]

36.50 [36.40, 36.50]

0.923

Pulse (beats per minute)

 

73.00 [66.00, 83.00]

75.00 [68.00, 81.00]

0.992

Respiration (breaths per minute)

 

18.00 [18.00, 18.00]

18.00 [18.00, 18.00]

0.392

Surgery duration (hours)

 

6.00 [5.00, 7.00]

6.50 [5.50, 7.50]

0.233

Intraoperative blood loss (mL)

 

100.00 [50.00, 100.00]

100.00 [57.50, 150.00]

0.185

Intraoperative Blood transfusion (mL)

 

0.00 [0.00, 0.00]

0.00 [0.00, 0.00]

0.057

Fibrinogen (g/L)

 

3.19 [2.70, 3.78]

3.21 [2.82, 3.85]

0.087

APTT (s)

 

24.80 [22.70, 27.20]

24.60 [22.08, 27.21]

0.475

PT (s)

 

11.10 [10.70, 11.60]

11.20 [10.80, 11.70]

0.242

Hemoglobin (g/L)

 

124.00 [110.00, 134.00]

118.00 [100.75, 131.00]

0.029

Platelet count (× 10⁹/L)

 

218.00 [180.00, 266.00]

226.50 [177.75, 274.25]

0.938

Preoperative triglycerides (mmol/L)

 

1.17 [0.87, 1.69]

1.06 [0.80, 1.44]

0.019

Postoperative triglycerides (mmol/L)

 

0.73 [0.54, 1.15]

0.65 [0.50, 1.17]

0.852

Preoperative total cholesterol (mmol/L)

 

4.80 [4.15, 5.55]

4.76 [4.16, 5.28]

0.225

Postoperative total cholesterol (mmol/L)

 

3.72 [3.14, 4.42]

3.69 [3.20, 4.20]

0.27

Preoperative HDL (mmol/L)

 

1.40 [1.19, 1.63]

1.40 [1.17, 1.64]

0.397

Postoperative HDL (mmol/L)

 

1.12 [0.96, 1.30]

1.10 [0.94, 1.29]

0.22

Preoperative LDL (mmol/L)

 

2.80 [2.35, 3.43]

2.76 [2.36, 3.18]

0.394

Postoperative LDL (mmol/L)

 

2.18 [1.75, 2.61]

2.16 [1.78, 2.52]

0.526

Preoperative creatinine (μmol/L)

 

69.00 [56.00, 82.00]

66.00 [56.00, 80.00]

0.263

Postoperative creatinine (μmol/L)

 

69.00 [56.00, 81.00]

70.00 [57.00, 83.00]

0.469

Postoperative CRP (mg/L)

 

24.60 [15.84, 39.70]

35.70 [20.20, 63.68]

 < 0.001

Preoperative D-Dimer (μg/mL)

 

0.38 [0.22, 0.77]

0.58 [0.32, 1.15]

0.001

Postoperative D-Dimer day1 (μg/mL)

 

3.07 [1.80, 4.95]

4.96 [3.06, 8.78]

 < 0.001

Postoperative D-Dimer day3 (μg/mL)

 

2.22 [1.44, 3.84]

3.45 [2.37, 5.66]

 < 0.001

Postoperative D-Dimer day5 (μg/mL)

 

2.33 [1.51, 3.69]

3.82 [2.57, 5.98]

 < 0.001

Postoperative D-Dimer day7 (μg/mL)

 

2.03 [1.09, 3.46]

3.98 [2.66, 6.09]

 < 0.001

Systolic Blood Pressure (mmHg)

 

135.00 [124.00, 150.00]

136.00 [125.00, 150.75]

0.459

Diastolic blood pressure (mmHg)

 

76.00 [69.00, 84.00]

75.00 [68.00, 81.00]

0.37

Preoperative eGFR (mL/min/1.73 m2)

 

91.80 [80.27, 100.23]

91.02 [81.80, 97.71]

0.52

Postoperative eGFR (mL/min/1.73 m2)

 

92.34 [80.27, 100.35]

89.03 [73.55, 97.85]

0.019

  1. Continuous variables are presented as median [interquartile range] due to non-normal distributions, and were compared using the Mann–Whitney U test. Categorical variables are presented as counts (percentages) and compared using the chi-square test or Fisher’s exact test, as appropriate.
  2. Abbreviations: 7dDDE, 7-day D-dimer Exposure; APTT, Activated Partial Thromboplastin Time; PT, Prothrombin Time; eGFR, Estimated Glomerular Filtration Rate.