Table 2 Clinical and fecal subclinical characteristics in persistent diarrhea children before, during, and after treatment.

From: High-dose multi-strain Bacillus probiotics enhance treatment and reduce antibiotic usage in children with persistent diarrhea through immune and microbiota modulation

Characteristic

Control group (N = 49)

Dia30 group (N = 48)

p value

Day 0

Day 3

Day 5

Day 0

Day 3

Day 5

Day 0

Day 3

Day 5

Typical symptoms

 Stools a day of ≥ 3 n(%)

49 (100)

41 (83.67)

38 (77.55)

48 (100)

34 (70.83)

14 (29.17)

> 0.9999a

0.1311b

< 0.0001b

 3–5 stools a day

25 (51.02)

30 (61.22)

33 (67.35)

24 (50.0)

32 (66.67)

13 (27.08)

0.9199b

0.5768b

< 0.0001b

 6–7 stools a day

18 (36.73)

10 (20.41)

4 (8.16)

17 (35.42)

1 (2.08)

0 (0.0)

0.8925b

0.0077a

0.1173a

 ≥ 8 stools a day

6 (12.24)

1 (2.04)

1 (2.04)

7 (14.58)

1 (2.08)

1 (2.08)

0.7354b

> 0.9999a

> 0.9999a

 Presence of fecal mucus n (%)

48 (97.96)

44 (89.80)

34 (69.39)

46 (95.83)

33 (68.75)

12 (25.0)

0.6171a

0.0104b

< 0.0001b

 Diaper stool types 4-5B n (%)

47 (95.92)

42 (85.71)

24 (48.98)

44 (91.67)

20 (41.67)

10 (20.83)

0.4357a

< 0.0001b

0.0037b

Subclinical test for stool n (%)

 Erythrocyte positive

(mild to severe)

30 (61.22)

15 (30.61)

5 (10.20)

21 (43.75)

10 (20.83)

1 (2.08)

0.0848b

0.2709b

0.2041a

 Leukocyte positive

(mild to severe)

44 (89.80)

25 (51.02)

6 (12.24)

46 (95.83)

10 (20.83)

0 (0.0)

0.4357a

0.002b

0.0266a

 pH ≤ 5.5

18 (36.73)

13 (26.53)

10 (20.41)

12 (25.0)

10 (20.83)

6 (12.5)

0.2112b

0.5095b

0.2941b

 pH > 5.5

31 (63.27)

36 (73.47)

25 (51.02)

36 (75.0)

38 (79.17)

12 (25.0)

0.0083b

  1. aFisher’s Exact test; bChi-Square test.