Fig. 6 | Scientific Reports

Fig. 6

From: miR-221 activates Sox11 to reduce brain injury after intracerebral hemorrhage via inhibiting neuroinflammation

Fig. 6

Increasing the expression level of Sox11 can maintain the integrity of the blood-brain barrier and inhibit brain edema. (A) The level of EB extravasation was increased in the rat brain after ICH, whereas it significantly reduced in mic-miR-221-treated rats. (B) The levels of ROS in the brain tissue of rats in various groups. (C) The levels of LDH in the CSF of rats in each group. (D) Brain water content was partially reduced by overexpression of Sox11. ICH group compared with the Sham group; ICH + mic-miR-221 group compared with the ICH + Vector group; ICH + Si-Sox11 group compared with the ICH + Si-Control group; **P < 0.01. All data are expressed as mean ± SD, n = 6.

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