Table 6 Radical Inhibition (%) by citrus species, plant parts, nanoparticle types, sizes, coatings, and control types.

From: Antioxidant and anticancer properties of citrus-mediated nanoformulations revealed by meta-analysis

 

k

Effect size

Heterogeneity

FsN

d++ ± SE

P value

I2

P value

Species

      

C. aurantium

29

−0.77 ± 0.4Rb.

0.055

74.9

< 0.001

270

C. clementina

20

0.55 ± 0.64NRb.

0.392

83.7

< 0.001

-

C. limetta

51

−0.87 ± 0.28Rb.

0.002

71.8

< 0.001

661

C. limon

26

2.25 ± 0.33Rb.

< 0.001

55.5

< 0.001

993

C. maxima

2

−1.53 ± 0.66NRb.

0.02

-

0.635

3

C. nobilis × C. deliciosa

1

1.93 ± 0.99NRb.

-

-

-

1

C. paradisi

3

3.05 ± 1.26Rb.

0.015

82.5

0.003

37

C. reticulata

48

1.03 ± 0.46NRb.

0.025

84.4

< 0.001

190

C. sinensis

15

−6.57 ± 1.55Rb.

< 0.001

87.6

< 0.001

377

Plant parts

      

Juice

11

−2.2 ± 2.01NRb.

0.273

90.7

< 0.001

-

Leaf

21

1.76 ± 0.3Rb.

< 0.001

42.8

0.02

496

Peel

139

−0.02 ± 0.25NRb.

0.952

82.7

< 0.001

78

Pomace

23

−0.93 ± 0.23Rb.

< 0.001

31

0.08

206

Seed

3

3.05 ± 1.26Rb.

0.015

82.5

0.003

37

Nanoparticle types

      

Ag-NP

59

1.04 ± 0.37Rb.

0.005

81.7

< 0.001

681

Ag chitosan-NP

5

4.92 ± 0.75Rb.

< 0.001

-

0.63

80

Au-NP

30

−1.11 ± 0.16Rb.

< 0.001

-

0.92

528

Au@Fe2O3-NPC

6

−8.95 ± 2.02Rb.

< 0.001

70.9

0.004

132

CdO-NP

10

−8.4 ± 1.76Rb.

< 0.001

87.5

< 0.001

235

CeO2-NP

5

2.47 ± 0.65Rb.

< 0.001

37.9

0.169

43

Co-NP

20

−2.42 ± 0.39Rb.

< 0.001

55.9

0.001

649

Fe3O4-NP

1

−0.86 ± 0.85NRb.

-

-

-

-

Hydrogel-NPC

3

3.05 ± 1.26Rb.

0.015

82.5

0.003

37

NiO-NP

20

−1.14 ± 0.23Rb.

< 0.001

18.6

0.223

237

Pectin-NPE

20

3.85 ± 0.62Rb.

< 0.001

75.8

< 0.001

817

TiO2-NP

6

2.06 ± 0.42Rb.

< 0.001

-

0.913

51

V-NP

4

−6.16 ± 2.78Rb.

0.027

90.4

< 0.001

63

Whey-NPE

8

4.04 ± 1Rb.

< 0.001

73

< 0.001

144

Sizes (nm)

      

1–50

90

0.77 ± 0.28Rb.

0.006

81.4

< 0.001

989

51–100

71

−1.56 ± 0.23Rb.

< 0.001

68.2

< 0.001

4,062

101–500

31

3.44 ± 0.544Rb.

< 0.001

79.2

< 0.001

1,437

> 500

6

−1.37 ± 0.303Rb.

< 0.001

63.6

< 0.001

100

Coatings

      

Citrus extract

166

−0.52 ± 0.2Rb.

0.009

80.2

< 0.001

2,422

Hydroxy propyl

methylcellulose

3

3.05 ± 1.26Rb.

0.015

82.5

0.003

37

Pectin

20

3.85 ± 0.62Rb.

< 0.001

75.8

< 0.001

817

Whey

8

4.04 ± 1Rb.

< 0.001

73.9

< 0.001

144

Control types

      

AgNO3

7

4.19 ± 0.55Rb.

< 0.001

-

1

143

Ascorbic acid

44

−3.1 ± 0.73Rb.

< 0.001

88

< 0.001

1,023

BHT

56

−1.13 ± 0.26Rb.

< 0.001

70.6

< 0.001

810

Catechol

5

−2.15 ± 0.47Rb.

< 0.001

-

0.491

38

C. clementina

10

3.19 ± 0.41Rb.

< 0.001

1.46

0.425

247

C. limetta

3

0.42 ± 0.48NRb.

0.384

-

0.972

-

C. limon

7

1.72 ± 0.36Rb.

< 0.001

-

0.999

52

C. nobilis × C. deliciosa

1

1.93 ± 0.99NRb.

-

-

-

1

C. reticulata

8

4.04 ± 1Rb.

< 0.001

73.9

< 0.001

144

C. unshiu

10

3.73 ± 0.86Rb.

< 0.001

74.7

< 0.001

201

Hydrogel films

3

3.05 ± 1.26Rb.

0.015

82.5

0.003

37

Pectin

10

4.12 ± 0.98Rb.

< 0.001

79.1

< 0.001

198

Sodium alginate

3

1.74 ± 0.55NRb.

0.002

-

0.949

9

Trolox

30

−1.11 ± 0.16Rb.

< 0.001

-

0.92

528

  1. The FsN value is considered robust (Rb.) if FsN ≥ 5k + 10, otherwise not robust (NRb.).
  2. BHT, butylated hydroxytoluene; d++, Hedges’ mean difference; FsN, fail-safe N; I2 heterogeneity derived from Cochran’s value; N, number of studies; NP, nanoparticle; NPC, nanocomposite; NPE, nanoemulsion; SE, standard error; Trolox, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid.