Fig. 1 | Scientific Reports

Fig. 1

From: Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

Fig. 1The alternative text for this image may have been generated using AI.

Flecainide shows superior beneficial effects in C57BL/6J EAE compared to phenytoin. Progression of EAE in C57BL/6J mice over 52 days post EAE induction, immunized with MOG35-55. Treatment with flecainide, safinamide, phenytoin and rasagiline was initiated from day 0. *p < 0.05; ***p < 0.001, ****p < 0.0001, area under the curve analyzed via ANOVA with Dunnett’s post hoc test in comparison to MOG EAE. n = 6 per group. Dotted lines represent the standard deviation.

Back to article page