Fig. 1 | Scientific Reports

Fig. 1

From: Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

Fig. 1

Flecainide shows superior beneficial effects in C57BL/6J EAE compared to phenytoin. Progression of EAE in C57BL/6J mice over 52 days post EAE induction, immunized with MOG35-55. Treatment with flecainide, safinamide, phenytoin and rasagiline was initiated from day 0. *p < 0.05; ***p < 0.001, ****p < 0.0001, area under the curve analyzed via ANOVA with Dunnett’s post hoc test in comparison to MOG EAE. n = 6 per group. Dotted lines represent the standard deviation.

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