Fig. 3 | Scientific Reports

Fig. 3

From: Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

Fig. 3The alternative text for this image may have been generated using AI.

Longitudinal evaluation of neurodegeneration and visual function via OCT and OMR reveals beneficial effects of flecainide and safinamide. OCT volume scan (A) of the degeneration of the inner retinal layers (IRL) (B, C), and OMR measurement of visual function (spatial frequency) (D) in cycles per degree (c/d) (E) in female C57BL/6J-EAE and NOD EAE mice over 90 days post EAE induction. **p < 0.01; ***p < 0.001, ****p < 0.0001, area under the curve analyzed via ANOVA with Dunnett’s post hoc test in comparison to MOG EAE. n = 9 per group.

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