Table 1 Biological processes enriched among the genes differentially expressed between HCC patients with or without lung recurrence after hepatectomy.
Category | Enrichment P-value | Gene count | Gene name |
|---|---|---|---|
Wound healing | < 0.001 | 63 | LOX, SERPINE2, DOCK8, SERPINE1, PLEK, TNC, HBB, ABAT, C4BPB, THBD, GJA1, PLAU, HNF4A, RAC2, TIMP1, CLIC1, PDGFRA, FGA, POSTN, FCER1G, ANXA1, SERPINB2, SLC11A1, ITGA2, ANXA5, SERPINF2, PLAUR, APOA5, F3, EREG, MMP12, F7, GAP43, F8, PKM, F9, TFF2, LCP2, TFF1, LCP1, S100A9, S100A8, HBEGF, CPB2, SERPINC1, ITPR2, PLG, PIK3R1, HIF1A, KNG1, PIK3R5, GNA15, MUSTN1, HMOX1, CYP4F2, F12, TFPI2, F11, CYP4F11, PROC, FAP, HPSE, HRG |
Response to steroid hormone | < 0.001 | 41 | LOX, THRB, MAOB, TAT, NR1I3, NR1I2, RORC, STC1, ADM, HNMT, PTGS2, AIF1, GHR, ALAD, CCND1, HNF4A, SPP1, CCL2, PMEPA1, CD38, PPARGC1A, PCK2, ANXA1, ANXA3, SRD5A1, IGFBP2, HMGA2, CYBA, CYP7B1, ASS1, ALDH3A1, AR, DAB2, CPS1, NEDD4, DDIT4, ADAM9, DSG2, CDO1, AGXT, TLR2 |
Response to decreased oxygen levels | < 0.001 | 37 | LOX, ACAA2, CXCR4, STC1, ITPR2, ADM, ABAT, PTGS2, HIF1A, NDRG1, LOXL2, ICAM1, ALAD, PLAU, CASP1, CCL2, HMOX1, PMAIP1, CD38, CA9, PCK1, PPARGC1A, BNIP3L, POSTN, EGLN3, PKLR, ITGA2, CYBA, ALDH3A1, F7, PKM, CLDN3, LEP, DDIT4, ANG, CD24, TLR2 |
Vasculature development | < 0.001 | 48 | LOX, FOXC1, SEMA3C, HPGD, C5AR1, SERPINE1, ADM, SEMA3E, PTGS2, PCSK5, HIF1A, LTBP1, LOXL2, SOCS3, GJA1, SRPX2, C6, GPNMB, SGCB, HYAL1, LEPR, PROK2, CCL2, HMOX1, PITX2, XDH, SOX4, TEAD2, PDGFRA, ANXA3, HGF, SERPINF2, LIF, KLF4, F3, EREG, FAP, CTH, IL1B, LEP, NEDD4, MMP19, ANG, HPSE, HRG, RAMP1, GPLD1, FGFR1 |
Extracellular matrix organization | < 0.001 | 31 | LOX, CPB2, FOXC1, ITGAM, SERPINE1, TNC, PLG, TNFRSF11B, LOXL2, ICAM1, TTR, ITGAX, SPP1, TIMP1, FGA, POSTN, MMP1, ITGA2, SERPINF2, LAMB1, MMP9, MMP10, SULF2, MMP12, VCAN, FAP, COL5A2, MMP19, LCP1, HPSE, CD44 |
Endothelial cell proliferation | < 0.001 | 12 | LOX, GJA1, HMOX1, CCL2, APOA1, ANG, CYBA, HIF1A, F3, XDH, LOXL2, CCL26 |
Lung development | < 0.001 | 9 | LOX, PDGFRA, LIT, PITX2, FGFR1, CASP1,CFTR, HMGCS2, MYCL1 |
Positive regulation of epithelium migration | < 0.01 | 21 | LOX, ANXA3, SEMA3A, ITGA2, APOA1, STC1, KLF4, PTGS2, HIF1A, MMP9, LOXL2, EPB41L5, SRPX2, FAP, HYAL1, ADAM9, S100P, HRG, GPLD1, HBEGF, FGFR1 |
