Table 3 Univariate and multivariate Cox regression to identify preoperative patient characteristics associated with risk of postoperative lung recurrence in HCC (n = 128).

Sex

Female vs. Male

1.293 (0.813–2.056)

0.277

Age (years)

≥ 45 vs. < 45 years

0.688 (0.482–0.982)

0.040*

0.625 (0.409–0.954)

0.029*

HBsAg

Positive vs. negative

1.794 (1.073–2.997)

0.026*

1.491 (0.838–2.656)

0.175

HBV-DNA (unit)

≥ 500 vs. < 500

1.146 (0.793–1.656)

0.467

AFP level (unit)

≥ 400 vs. < 400

2.247 (1.505–3.355)

< 0.001*

1.554 (0.989–2.441)

0.056

Tumor capsule▲

Incomplete vs. complete

2.419 (1.646–3.554)

< 0.001*

1.938 (1.254–2.995)

0.003*

Resection margin

≥ 1 cm vs. <1 cm

0.884 (0.598–1.306)

0.535

Tumor size▲

d ≥ 5 cm vs. d < 5 cm

2.227 (1.383–3.586)

0.001*

1.346 (0.795–2.282)

0.269

Node number

≥ 2 vs. 1

1.995 (1.373–2.898)

< 0.001*

1.659 (0.908–3.030)

0.100

KI67-LI

-

3.462 (1.664–7.203)

0.001*

2.172 (0.900-5.242)

0.084

BCLC stage

< 0.001*

0.421

 A

1.000(reference)

 B

B vs. A

2.131 (1.366–3.325)

< 0.001*

0.859 (0.412–1.789)

0.694

 C

C vs. A

3.586 (2.256–5.701)

< 0.001*

0.295 (2.356–0.474)

0.295

MVI

With vs. without

3.032 (1.886–4.875)

< 0.001*

1.919 (1.091–3.377)

0.024*

PVTT

With vs. without

2.614 (1.695–4.031)

< 0.001*

0.586 (0.129–2.656)

0.489

Liver cirrhosis

Moderate-severe vs. without/mild

1.371 (0.888–2.118)

0.155

LOX

Poor expression vs. high expression

3.029 (2.010–4.567)

< 0.001*

2.048 (1.309–3.204)

0.002*