Table 2 Univariable and multivariate Cox regression analysis of characteristics associated with OS.

From: Melanoma GPA as a novel prognostic scoring model based on initial brain metastasis velocity

Characteristics

Univariable analysis

Multivariable analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

Age

0.97 (0.65–1.44)

0.872

  

Sex

0.74 (0.50–1.11)

0.143

  

Date of BM

0.35 (0.22–0.55)

< 0.001

  

Number of BM

1.60 (1.07–2.39)

0.022

  

iBMV

2.36 (1.53–3.63)

< 0.001

1.65 (1.04–2.62)

0.035

Primary site

0.91 (0.54–1.52)

0.719

  

1.93 (1.03–3.60)

0.040

  

1.82 (0.42–7.77)

0.422

  

1.33 (0.63–2.82)

0.459

  

KPS

6.09 (3.46–10.72)

< 0.001

5.68 (3.01–10.73)

< 0.001

LDH

1.63 (1.09–2.45)

0.017

1.61 (1.05–2.46)

0.028

Alb

0.52 (0.35–0.79)

0.002

0.56 (0.32–0.98)

0.041

LMR

0.65 (0.43–0.99)

0.041

0.65 (0.41–1.05)

0.077

NLR

1.73 (1.13–2.63)

0.010

0.94 (0.54–1.63)

0.826

PLR

2.22 (1.47–3.37)

< 0.001

1.16 (0.65–2.06)

0.626

PNI

0.60 (0.39–0.90)

0.014

1.54 (0.84–2.81)

0.166

SII

1.94 (1.29–2.92)

0.001

1.72 (1.02–2.92)

0.042

Meningeal metastasis

0.93 (0.55–1.59)

0.797

  

Maximum diameter of BM

1.15 (0.76–1.76)

0.508

  

Cerebral hemorrhage

0.85 (0.50–1.47)

0.570

  

BM with a midline shift

0.61 (0.34–1.10)

0.098

  

Extracranial metastasis

0.61 (0.34–1.10)

0.098

  

Clinical syndromes

0.66 (0.43–1.01)

0.057

  
  1. OS, overall survival; HR, hazard ratio; CI, confidence interval; BM, brain metastasis, iBMV, initial brain metastasis velocity; KPS Karnofsky performance status, LDH, serum lactate dehydrogenase; Alb, serum albumin; LMR, lymphocyte-to-monocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index; SII, systemic immune-inflammation index.
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