Table 2 The list of genes which were downregulated or upregulated by AP treatment that shows statistical significance (P < 0.05) compared to differentiation control performed by NanoString analysis.

From: Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood

Gene symbol

Gene name

Fold change

P value

Gene ID

HSC stemness

 ADAM10

Human ADAM metallopeptidase domain

1.27

0.00003

NM_001110.2

 ALDH7A1

Aldehyde dehydrogenase 7 family, member A1

1.52

0.00017

NM_001202404.1

 ALDH9A1

Aldehyde dehydrogenase 9 family member A1

1.23

0.00193

NM_000696.3

 CD34

CD34

2.06

0.00002

NM_001025109.1

 GATA3

GATA binding protein 3

2.03

0.02395

NM_001002295.1

 MEIS1

Meis homeobox 1

1.28

0.01317

NM_002398.2

Wnt signaling pathway

 BAMBI

ETS variant 1

1.34

0.00458

NM_012342.2

 CACYBP

Leukemia inhibitory factor

1.15

0.00146

NM_014412.2

 CTBP1

AMP responsive element binding protein 5

1.12

0.03374

NM_001328.2

 CTNNB1

Transcription factor 7-like 1

1.15

0.00955

NM_001098210.1

 NLK

Kruppel-like factor 4

1.21

0.00667

NM_016231.4

 SKP1

cAMP responsive element binding protein 3-like 1

1.17

0.00001

NM_006930.3

 TBL1X

Latent transforming growth factor beta binding protein 1

1.31

0.00029

NM_005647.4

TGFB and SMAD signaling pathway

 LEFTY2

Phosphoinositide-3-kinase, regulatory subunit 2

1.46

0.02675

NM_003240.2

 NOG

FA complementation group L

1.48

0.03037

NM_005450.4

 SMAD2

Protein kinase C alpha

1.11

0.01511

NM_001003652.3

 TGFB1

Fas (TNF receptor superfamily, member 6)

1.32

0.00059

NM_000660.3

 TGFBI

Phosphoinositide-3-kinase, catalytic, beta polypeptide

1.58

0.02251

NM_000358.2

 G6PC3

Phosphoinositide-3-kinase regulatory subunit 3

1.27

0.00660

NM_138387.3

 PRKAG2

Human protein kinase, AMP-activated, gamma 2 non-catalytic subunit

1.36

0.00358

NM_016203.3

JAK-STAT and AMPK signaling pathway

 JAK1

Janus kinase 1

1.19

0.00071

NM_002227.1

 PTPN6

Protein tyrosine phosphatase, non-receptor type 6

1.38

0.00003

NM_002831.5

 SOCS2

Suppressor of cytokine signaling 2

1.58

0.00021

NM_003877.3

 STAT1

Signal transducer and activator of transcription 1

1.26

0.00907

NM_007315.3

 DUSP7

Dual specificity phosphatase 7

1.36

0.00240

NM_001947.2

 FLNB

Filamin B

1.24

0.00080

NM_001164317.1

 RASGRP2

RAS guanyl releasing protein 2

1.34

0.00204

NM_001098671.1

 VEGFC

Vascular endothelial growth factor C

1.53

0.00077

NM_005429.2

Hippo signaling pathway

 LIMD1

LIM domains containing 1

1.12

0.02612

NM_014240.2

 PARD3

Par-3 partitioning defective 3 homolog

1.23

0.00138

NM_019619.2

 YWHAB

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

1.1

0.00334

NM_139323.3

 YWHAE

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

1.1

0.00002

NM_006761.4

 YWHAG

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

1.25

0.00445

NM_012479.4

Cell adhesion and ECM

 FYN

FYN related to SRC, FGR, YES

1.18

0.00998

NM_002037.3

 ITGA5

Integrin, alpha 5

1.48

0.00007

NM_002205.2

 RAP1B

RAP1B, member of RAS family

1.32

0.00008

NM_015646.5

 ROCK2

Rho associated coiled-coil containing protein kinase 2

1.15

0.00045

NM_004850.3

 SHC1

SHC adaptor protein 1

1.22

0.00476

NM_001130040.1

 SRC

Schmidt-Ruppin A-2

1.77

0.00007

NM_005417.3

 TLN1

Talin 1

1.16

0.00064

NM_006289.3

 FOSL2

FOS like 2

1.35

0.00094

NM_005253.3

 ITGA2B

Integrin subunit alpha 2b

1.29

0.00130

NM_000419.3

 ITGB3

Integrin subunit beta 3

1.27

0.00015

NM_000212.2

Cell cycle, cellular senescence, HSC differentiation and cancer related genes

 ATM

ATM

− 1.4

0.00005

NM_000051.3

 SIRT1

Sirtuin 1

− 1.13

0.00278

NM_012238.4

 SLC25A4

Solute carrier family 25, member 4

− 1.21

0.04906

NM_001151.4

 CACNA2D2

Calcium channel, voltage-dependent, alpha 2/delta subunit 2

− 1.65

0.00692

NM_001005505.1

 E2F5

E2F transcription factor 5

− 1.2

0.04059

NM_001083588.1

 PLCG1

Phospholipase C gamma 1

− 1.63

0.00110

NM_002660.2

 CDH1

Cadherin 1, type 1, E-cadherin

− 3.23

0.00012

NM_004360.2

 EPCAM

Epithelial cell adhesion molecule

− 2.14

0.00000

NM_002354.2

 EXT1

Exostosin glycosyltransferase 1

− 1.86

0.00366

NM_000127.2

 LUM

Lumican

− 2.02

0.00963

NM_002345.3

 ID2

Inhibitor of DNA binding 2

− 1.78

0.00003

NM_002166.4

 BMPR1A

Bone morphogenetic protein receptor type 1 A

− 3

0.00383

NM_004329.2

 LDB1

LIM domain binding 1

− 1.47

0.00005

NM_001113407.1

 TGM2

Transglutaminase 2

− 2.75

0.00007

NM_004613.4

 TET1

Tet methylcytosine dioxygenase 1

− 1.48

0.03371

NM_030625.2

 MAF

MAF bZIP transcription factor

− 1.45

0.00935

NM_005360.4

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