Table 2. The independent variables levels used to formulate C.O.-loaded PLGA-PCL NPs.

From: Antiviral potential of Corchorus olitorius fixed oil loaded into poly(D,L-lactide-co-glycolide)/poly(ε-caprolactone) (PLGA/PCL) nanoparticles against HSV-1 virus, supported by network analysis

Formula

No.

Independent

Response

X1:

volume of oil (mL)

X2:

amount of PLGA

X3:

amount of PCL

Y1: entrapment efficiency (EE%)

Y2:

size of vesicles

Y3:

zeta potential (ZP)

Y4: polydispersity index

(PDI)

F1

0.4

16

16

56.8 ± 0.63

569.4 ± 0.24

−17 ± 0.02

0.574 ± 0.21

F2

0.4

16

14

59.8 ± 0.41

502.4 ± 0.61

−17.1 ± 0.03

0.451 ± 0.22

F3

0.2

14

16

30.2 ± 0.36

781.2 ± 0.51

−13.5 ± 0.05

0.514 ± 0.14

F4

0.6

14

14

59.8 ± 0.41

502.4 ± 0.02

−18 ± 0.02

0.451 ± 0.20

F5

0.2

16

14

51.3 ± 0.61

487.4 ± 0.41

−19.1 ± 0.03

0.501 ± 0.01

F6

0.2

18

12

41.8 ± 0.25

612.2 ± 0.31

−18 ± 0.01

0.521 ± 0.21

F7

0.4

16

14

63.8 ± 0.54

780.2 ± 0.42

−13.6 ± 0.01

0.489 ± 0.01

MCO-F8

0.6

18

16

77.5 ± 0.44

151.2 ± 0.24

−25.6 ± 0.04

0.326 ± 0.04

F9

0.2

18

16

49.1 ± 0.36

541.4 ± 0.34

−18.7 ± 0.03

0.514 ± 0.41

F10

0.4

18

12

58.4 ± 0.41

841.2 ± 0.41

−23.3 ± 0.0.12

0.394 ± 0.07

F11

0.4

18

14

42.3 ± 0.35

521.3 ± 0.81

−14.5 ± 0.02

0.53 ± 0.05

F12

0.2

16

14

51.3 ± 0.41

487.4 ± 0.14

−19.1 ± 0.14

0.501 ± 0.05

F13

0.4

16

16

59.4 ± 0.24

364.1 ± 0.61

−20.1 ± 0.02

0.418 ± 0.04

F14

0.6

16

12

48.4 ± 0.42

604.1 ± 0.36

−19.1 ± 0.04

0.591 ± 0.15

F15

0.4

14

12

55.8 ± 0.35

748.2 ± 0.41

−22.4 ± 0.04

0.514 ± 0.04

F16

0.2

14

12

36.5 ± 0.21

781.5 ± 0.54

−22.4 ± 0.21

0.514 ± 0.04

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