Fig. 5 | Scientific Reports

Fig. 5

From: Characterization of the effects of oxymatrine on myocardial hypertrophy in spontaneously hypertensive rats through transcriptomics and metabolomics

Fig. 5

Effect of OMT on the mRNA and protein expression levels of Cyp2e1. (a) RT-qPCR analysis of Cyp2e1 mRNA expression in the left ventricle. (b) RT-qPCR analysis of expression of myocardial-hypertrophy-associated genes (ANP and BNP) in the left ventricle. (c) Immunohistochemistry staining of Cyp2e1 protein in the left ventricle. Scale bar = 50 μm. (d) The H-score statistics of Cyp2e1 immunostaining in panel B. (e) ELISA analysis for DOC level in serum of difference groups. (f) ELISA analysis for DOC level in left ventricle of difference groups. ****P < 0.001; ***P < 0.005; **P < 0.01; *P < 0.05. ANP: Atrial natriuretic peptide; BNP: B-type natriuretic peptide; DOC: Deoxycorticosterone; OMT: Oxymatrine; SHRs: Spontaneously hypertensive rats; WKY: Wistar-Kyoto rats.

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