Fig. 1 | Scientific Reports

Fig. 1

From: Metabolic dysfunction impairs Mycobacterium tuberculosis-specific cytokine and chemokine responses in latent tuberculosis and type 2 diabetes mellitus

Fig. 1

Association between DM and Mtb-specific Th1 and inflammatory cytokine and chemokine responses. (A) PCA of supernatant cytokines and chemokines using the first two principal components. The ellipses were centred based on the median of PC1 and PC2 for NDM (blue, n = 100) and DM (red, n = 64). (B) Volcano plot showing differentially expressed cytokines and chemokines for DM versus NDM. The analysis was performed using a linear regression model with age and LTBI status as covariates. Each dot represents a cytokine or chemokine, with the x-axis showing the Log2FC and the y-axis showing the -Log10[adj.P.Val]. The upregulated cytokines or chemokines are shown in red, downregulated in blue, and the non-significant in grey. The dashed horizontal line represents the threshold for statistical significance (FDR-adjusted [adj.P.Val] < 0.050). Abbreviations: DM–Diabetes mellitus; NDM–No diabetes mellitus.

Back to article page