Fig. 3

H9SNTA1KO derived cardiomyocytes showed shorter field potential duration and slower conduction velocity. A. Schematic of MAESTRO™ MEA SYSTEMS work flow. B. The image of cardiomyocytes seeded on the Micro-electrode plate. Scale bar: 10 μm. C’. The image of Continuous Waveform Plots for WT cardiomyocytes and KO cardiomyocytes. C’’. The statistical of beat period of the WT cardiomyocytes and KO cardiomyocytes. There is a statistical difference between them. N = 9, ****P < 0.0001. The beat period of KO cardiomyocytes was shorter than that of WT. D’. The Schematic of beat Metrics. D’’. The image of cardiac voltage waveforms for WT cardiomyocytes and KO cardiomyocytes. D’’’. The statistical FPD diagram of WT cardiomyocytes and KO cardiomyocytes. The MEA results indicates that the FPD of KO cardiomyocytes is shorter than that of WT. There is a statistical difference. N = 9, ****P < 0.0001. E. The propagation map of WT cardiomyocytes and KO cardiomyocytes. F. The MEA results showing the conduction velocity of KO cardiomyocytes is slower than the WT cardiomyocytes. There is a statistical difference. N = 3, *P < 0.05.