Fig. 3
(A) Comparison of IgHr positive rate between single biopsy and repeat biopsy. IgHr in single and repeat biopsies was 69.5% and 90.8%, respectively. IgHr positive rate increased significantly by repeat biopsy. (B) IgHr and pathological status post-pathological complete response (CR). Among the 17 patients who were IgHr-negative and pathological negative upon achieving an initial pathological CR, all remained negative after 2 years. Of the 24 pathological negative but IgHr-positive cases at the time of pathological CR, 16 (66.7%) converted to both negative, four (16.7%) remained IgHr-positive after 2 years, and four (16.7%) experienced recurrence based on pathological findings. (C) Recurrence rate based on initial IgHr status at pathological CR. A comparison between cases with IgHr-positivity on pathological CR and those with both IgHr-negative and pathological negative statuses revealed a recurrence rate of 16.7% in IgHr-positive cases, indicating a significantly higher recurrence frequency in this group. (D) IgHr positivity trends following pathological CR. The rate of IgHr positivity in patients who achieved pathological CR gradually decreased over time, suggesting a potential time lag between achieving pathological CR and the subsequent IgHr-negative conversion.
